Confounders and intermediaries in case–control study designs: a strategy for distinguishing between the two when measured using the same variable
Identifieur interne : 001872 ( Main/Exploration ); précédent : 001871; suivant : 001873Confounders and intermediaries in case–control study designs: a strategy for distinguishing between the two when measured using the same variable
Auteurs : Andrea Gruneir [Canada] ; Connie Marras [Canada] ; Hadas Fischer [Canada] ; Xuesong Wang [Canada] ; Sudeep Gill [Canada] ; Paula A. Rochon [Canada] ; Geoffrey M. Anderson [Canada]Source :
- Pharmacoepidemiology and Drug Safety [ 1053-8569 ] ; 2011-03.
English descriptors
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Abstract
An intermediary falls within the exposure–outcome pathway and is distinct from a confounder. In case–control studies, it may be difficult to discern between the two when both are measured by the same variable. Using data from a study on the effects of antipsychotic initiation on risk of death among older adults, where hospital use is both a confounder and intermediary, we illustrate the bias introduced when this distinction is overlooked and propose a modified exposure classification strategy to mitigate this.
Url:
DOI: 10.1002/pds.2058
Affiliations:
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In case–control studies, it may be difficult to discern between the two when both are measured by the same variable. Using data from a study on the effects of antipsychotic initiation on risk of death among older adults, where hospital use is both a confounder and intermediary, we illustrate the bias introduced when this distinction is overlooked and propose a modified exposure classification strategy to mitigate this.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Gruneir, Andrea" sort="Gruneir, Andrea" uniqKey="Gruneir A" first="Andrea" last="Gruneir">Andrea Gruneir</name></noRegion><name sortKey="Anderson, Geoffrey M" sort="Anderson, Geoffrey M" uniqKey="Anderson G" first="Geoffrey M." last="Anderson">Geoffrey M. Anderson</name><name sortKey="Anderson, Geoffrey M" sort="Anderson, Geoffrey M" uniqKey="Anderson G" first="Geoffrey M." last="Anderson">Geoffrey M. Anderson</name><name sortKey="Anderson, Geoffrey M" sort="Anderson, Geoffrey M" uniqKey="Anderson G" first="Geoffrey M." last="Anderson">Geoffrey M. Anderson</name><name sortKey="Fischer, Hadas" sort="Fischer, Hadas" uniqKey="Fischer H" first="Hadas" last="Fischer">Hadas Fischer</name><name sortKey="Gill, Sudeep" sort="Gill, Sudeep" uniqKey="Gill S" first="Sudeep" last="Gill">Sudeep Gill</name><name sortKey="Gruneir, Andrea" sort="Gruneir, Andrea" uniqKey="Gruneir A" first="Andrea" last="Gruneir">Andrea Gruneir</name><name sortKey="Gruneir, Andrea" sort="Gruneir, Andrea" uniqKey="Gruneir A" first="Andrea" last="Gruneir">Andrea Gruneir</name><name sortKey="Gruneir, Andrea" sort="Gruneir, Andrea" uniqKey="Gruneir A" first="Andrea" last="Gruneir">Andrea Gruneir</name><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A." last="Rochon">Paula A. Rochon</name><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A." last="Rochon">Paula A. Rochon</name><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A." last="Rochon">Paula A. Rochon</name><name sortKey="Wang, Xuesong" sort="Wang, Xuesong" uniqKey="Wang X" first="Xuesong" last="Wang">Xuesong Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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